Supply Chain Management (SCM) is crucial to be present in global markets as nowadays competition is between supply chains rather than between companies. Current SCM paradigms like Lean, Agile, Resilient, and Green (LARG) are usually presented as individual management philosophies. The current challenge is to make the supply chain more competitive, capable of responding to the demands of custome...

In recent years, taking advantage of LARG supply chain (SC) paradigm, a combination of four paradigms (clean, agile, resilience and green) has been increasingly employed. For capturing the advantages of LARG in SC, companies needed to recognize proper practices and implement them with appropriate planning and infrastructure. However, one of its deficiencies is lack of proper method in the prior...

Supply chains (SC) in an attempt to be more competitive, are adopting new management paradigm. Among these paradigms there are four that deserve particular mention because of their importance to better SC performance: lean, agile, resilient and green. The main objective of this paper is to propose a conceptual model for a lean, agile, resilience and green SC, with the purpose of improving their...

Bearing in mind the new Supply Chain Management (SCM) paradigms, it is important that supply chains be aware of the implementation level of the main practices associated to each SCM paradigm (Lean, Agile, Resilient, and Green, hereafter referred as LARG). The main objective of this chapter is to propose a framework, based on Enterprise 2.0 approach, for global supply chains to assess their LARG...

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) was originally identified as a fusion partner with mixed-lineage leukemia in a patient with acute myeloid leukemia. LARG possesses a tandem Dbl homology and pleckstrin homology domain structure and, consequently, may function as an activator of Rho GTPases. In this study, we demonstrate that LARG is a functional Dbl protein. Expr...

Semaphorins are axon guidance molecules that signal through the plexin family of receptors. Semaphorins also play a role in other processes such as immune regulation and tumorigenesis. However, the molecular signaling mechanisms downstream of plexin receptors have not been elucidated. Semaphorin 4D is the ligand for the plexin-B1 receptor and stimulation of the plexin-B1 receptor activates the ...

Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have identified a unique signaling mechanism by which RSK2 promotes cell motility through leukemia-ass...

Rho GTPases are integral to the regulation of actin cytoskeleton-dependent processes, including mitosis. Rho and leukemia-associated Rho guanine-nucleotide exchange factor (LARG), also known as ARHGEF12, are involved in mitosis as well as diseases such as cancer and heart disease. Since LARG has a role in mitosis and diverse signaling functions beyond mitosis, it is important to understand the ...

Proper completion of mitosis requires the concerted effort of multiple RhoGEFs. Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the intercellular membrane is cleaved between daughter cells. LARG colocalizes with α-tubulin at the spindle poles before localizing to the central spindle. During cyt...

The purpose of this study is to compare the efficacy of laparoscopy-assisted radical gastrectomy (LARG) versus that of open radical gastrectomy (ORG). Clinical data of 355 patients who underwent radical gastrectomy (160 in the LARG group and 195 in the ORG group) were analyzed retrospectively. Efficacy indices were compared and analyzed between the two groups. The operating time of LARG was lon...